Focal benign disorders of the pediatric mandible with. Histologically, odontogenic keratocysts are characterized by the presence of an external connective tissue capsule, with. Cysts that derive their epithelium from tissues involved in tooth formation are classed odontogenic and can be inflammatory or developmental in origin. Orthokeratinized odontogenic cyst ooc is a rare, developmental odontogenic cyst which was considered in the past to be a variant of keratocystic odontogenic tumor kcot. Of note, a dentigerous cyst is, by definition, always associated with an unerupted tooth. Full text pdf 2305k abstracts references12 citedby1. Odontogenic keratocyst okc is a developmental cyst of tooth origin with an aggressive behaviour including high recurrence rate.
The orthokeratinized odontogenic cyst ooc is a rare developmental jaw cyst. Although orthokeratinized odontogenic cyst ooc was first described as early as in 1927 by schultz1, it was first considered to be a variant of okc. Ooc is characterised by a lessaggressive behaviour and a low rate of recurrence. Clinical study of keratocystic odontogenic tumor and. Odontogenic keratocyst okc is an aggressive cyst and its recurrence is higher than other odontogenic cysts, orthokeratinized odontogenic cyst ooc is a cyst with moderate biological behavior in. Glandular odontogenic cyst the glandular odontogenic cyst goc is a rare lesion, accounting for just 0. Calcifying odontogenic cyst calcifying ghost cell odontogenic cyst, calcifying cystic odontogenic tumor about 1% of cysts. Odontogenic cysts, odontogenic tumors, fibroosseous, and. It is more common in the mandible region and in the male sex. Immunohistochemical expression of ncam, using a monoclonal antibody, was determined in a series of 58 kpocs comprising 12. Odontogenic cysts, tumors, and related jaw lesions ento key. According to the 2005 world health organizations classification. Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by. Radicular cyst is the most common up to two thirds of all cysts of the jaws.
Dentigerous cyst, or follicular cyst, is not only the most common pediatric odontogenic cyst, it is the most frequently encountered lesion of the mandible in children after dental caries 5, 6. The treatment of ooc is by enucleation and the prognosis, following enucleation is excellent with a recurrence rate of less than 2%. In addition to keratocystic odontogenic tumor kcot, orthokeratinized odontogenic cyst ooc has recently been. Odontogenic keratocysts located in the buccal mucosa. Mesenchymal lesions of the oral cavity pdf free download. Infected orthokeratinized odontogenic cyst 615 cyst is relatively rare 3,7.
Recognition of ooc as a unique entity has long been due, yet its inexplicable radiographic presentation resembling dentigerous cyst, histological likeness to odontogenic keratocyst okc and inconsistent cytokeratin expression profiles overlapping with both as well as with the epidermis, makes it rather. The orthokeratinized odontogenic cyst is a relatively rare developmental odontogenic cyst of the jaws that occurs predominantly in males between the third and fourth decades. Various studies have shown that ooc has typical characteristic clinicopathologic. Calcifying odontogenic cyst associated with dentigerous. Comparative expression profiles of keratins and apoptosis regulating proteins in keratocystic odontogenic tumor, orthokeratinized odontogenic cyst, and dentigerous cyst. Odontogenic keratocyst okc has a special mention in the field of oral and maxillofacial surgery due to its varied presentation and high recurrence rate. Orthokeratinized odontogenic cyst ooc is a rare intraosseous cyst characterized by an orthokeratinized epithelial lining and minimal clinical aggressiveness. This report describes a case of ooc involving posterior part of the mandible that mimicked periapical cyst in a 14yearold boy. Kpocs included orthokeratinised odontogenic cyst ooc and parakeratotic odontogenic cysts, which are now considered true tumours denominated keratocystic odontogenic tumours kcots. Orthokeratinized odontogenic cyst ooc is a benign odontogenic cyst. Orthokeratinized odontogenic cyst with an associated keratocystic odontogenic tumor component and ghost cell keratinization and calcifications in a patient with gardner syndrome. Recognition of ooc as a unique entity is of utmost importance as it bears.
They were first identified by wright in 1981 and were originally thought to be part of the spectrum of odontogenic keratocyst okc. Orthokeratinized odontogenic cyst ooc is a rare, developmental odontogenic cyst which was considered in the past to be a variant of odontogenic keratocyst okc later renamed as keratocystic odontogenic tumor kcot. Orthokeratinized odontogenic cyst ooc is a developmental odontogenic cyst characterised by a lining of orthokeratinized stratified squamous epithelium. To investigate immunohistochemically the expression of neural cell adhesion molecule ncam, which has been identified as a signaling receptor with frequent reactivity in ameloblastomas ab, in a series of keratinproducing odontogenic cysts kpocs. In 1981, wright identified it, owing to its different histology and relatively low recurrence rate, as orthokeratinized variant of odontogenic keratocyst okc. Orthokeratinized odontogenic cyst arising from dentigerous. Although both the first two editions of the world health organizations who histological classification of odontogenic tumours recognized that cases with.
Immunohistochemical expression of glucose transporter 1 in. These cysts show variable features and some lie on a cysttumour interface, making classification and diagnosis difficult. The histopathologic and clinical features of sixty cases of orthokeratinized odontogenic cysts were compared with those. Odontogenic cysts have histologic origins in the cells of the dental structures. Unlike the kcot, the orthokeratinized odontogenic cyst is lined by. Pdf orthokeratinized odontogenic cyst masquerading as. Although both the first two editions of the world health organizations who histological classification of odontogenic tumours recognized that cases. Calcifying odontogenic cyst coc is a rare odontogenic cyst with ameloblastic epithelial lining containing clusters of ghost cells. However, there is no statement concerning orthokeratinized okc. Orthokeratinised odontogenic cyst mimicking periapical. Clinical study of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst.
Keratinproducing odontogenic cysts kpocs are a group of cystic lesions that are often aggressive, with high rates of recurrence and multifocality. The orthokeratinized odontogenic cyst ooc 1 was first clearly identified as an orthokeratinzed variant of the odontogenic keratocyst by wright in 1981 2 owing to its different histopathology and reduced likelihood to recur. Pdf orthokeratinized odontogenic cyst of the maxilla. It results from expansion and fluid accumulation within remnants of the dental lamina and usually presents in the second decade of life 7. Classification odontogenic cysts how does a cyst form. The orthokeratinized odontogenic cyst is considered by some to be a unique cyst, and by others to be a variant of the kcot.
Clinically, it presents no tendency to relapse due to low local aggressiveness, and is not associated with the nevoid basal cell carcinoma syndrome nbccs. Some are inflammatory while others are developmental. Orthokeratinized odontogenic cyst with an associated. Lateral periodontal cyst glandular odontogenic cyst unclassified paradental cyst calcifying odontogenic cyst 9. Another example of a presumably odontogenic cyst that is somewhat comparable to okc is the orthokeratinized odontogenic cyst ooc, although they show distinctive histological and clinical differences, mainly in their recurrence rate which is substantially lower than that in okcs. It is much less common than the kcot and has a much lower recurrence rate. Lesions of the oral cavity precancerous lesions of the oral cavity tumorous lesions involving the oral cavity oral melanoma and other pigmented lesions of the oral cavity precancerous lesions in the oral cavity. The databases searched were the pubmed interface of medline and lilacs. The aim of the present study was to compare the proliferation index of the epithelial cells between odontogenic keratocysts okc, orthokeratinized odontogenic cysts ooc, dentigerous. The presence of bcl2 and cytokeratin 10 along with interleukins in the basal and suprabasal layers led to the inhibition of apoptosis of the surface epithelium and hence the high rate of recurrence. However, it mostly occurs during the second and third decades of life. Odontogenic cysts that can be problematic because of recurrence andor aggressive growth include odontogenic keratocyst okc, calcifying. The odontogenic keratocyst okc may occur at any age. This case report describes a rare malignant transformation of ooc, with the aim of raising awareness of the malignant potential of ooc and distinguishing it from okc.
Orthokeratinized odontogenic cyst critical appraisal of a distinct entity ovi dental. Glut1 is a protein transporter that is involved in the. All cases were submitted for p16ink4a immunohistochemical. In this video, i discuss the main mechanisms involved in the formation of three most important odontogenic cysts, namely. Cocs have been described in association with several odontogenic tumors, more commonly odontomas and rarely with dentigerous cyst dc. Its incidence varies among different series, ranging from 16. A comparative study of epithelial cell proliferation between the odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst, and. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst of the jaw constituting about 10%. Compared to other odontogenic cysts, this type occurs with a frequency of 515%. This inflammatory cyst originated from a reaction to dental pulp necrosis dentigerous cyst, the second most prevalent cyst, is associated with the crown of nonerupted tooth. Also orthokeratinized odontogenic cyst can mimic typical characteristic clinicopathologic features of some other developmental odontogenic lesions such as dentigerous cyst and the odontogenic keratocyst, there is no previous report based on transforming of dentigerous cyst to orthokeratinized odontogenic cyst. In 2005, the world health organisation who reclassified the okc as keratocystic odontogenic. Odontogenic cysts are largely classified based on their location, viability of the associated tooth and clinical setting. A male preference has been reported for ooc, with a maletofemale ratio of 2.
Orthokeratinized odontogenic cyst ooc is a developmental cyst that occurs in the maxilla and the mandible and is defined by the world health organization as the uncommon orthokeratinized type of odontogenic keratocyst okc. Read orthokeratinized odontogenic cyst of the mandible with heterotopic cartilage, head and neck pathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Cureus management of the odontogenic keratocyst six. Orthokeratinized odontogenic cyst ooc is an odontogenic cyst was initially termed as the uncommon orthokeratinized type of odontogenic keratocyst by the world health organization.
In the histological classification of who in 2005, parakeratinized okc was classified as keratocystic odontogenic tumor kcot. Pdf the orthokeratinized odontogenic cyst ooc is a rare developmental odontogenic cyst that has been considered as a variant of the keratocystic. Comparative expression profiles of keratins and apoptosis. Unlimited viewing of the articlechapter pdf and any associated supplements and figures.
The orthokeratinized odontogenic cyst may share some histologic features with okc but is orthokeratinized not parakeratinized and lacks the palisaded basal cell layer. Odontogenic cysts, tumors, and related jaw lesions. Orthokeratinised odontogenic cyst ooc denotes the odontogenic cyst that microscopically has an orthokeratinised epithelial lining. Ncam cd56 expression in keratinproducing odontogenic. A comparative study of epithelial cell proliferation. It is a variant of the common odontogenic keratocyst okc. Orthokeratinized odontogenic cyst ooc is also a developmental cyst occurring in the tooth bearing regions of jaws and is defined by the world health organisation as the uncommon orthokeratinized type of odontogenic keratocyst okc. A dentigerous cyst results because of the enlargement of the follicular space of the whole or part of the crown of an impacted or. Oocs were first described in 1927 by schultz as a variant of odontogenic keratocysts, now known as. Orthokeratinized odontogenic cyst ooc is a relatively rare lesion of the jaws, mainly located in the posterior segment of the mandible.
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